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This indicates tolerability in most patients when supervised

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Given their involvement in sensing luminal contents and secreting hormones, EECs are increasingly recognized as contributors to the progression of various diseases, including IBD, IBS, metabolic diseases, neurogenerative diseases, as well as diseases of unregulated hormonal over-release like Zollinger-Ellison syndrome, a rare condition characterized by unregulated overproduction of gastrin, a hormone that stimulates the secretion of gastric acid 80 , and Carcinoid Syndrome, which is caused by neuroendocrine tumours, usually in the small intestine, which overproduce serotonin and other vasoactive substances 81