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Methods Animal preparation The animal care and experimental protocols conformed to the recommendations in the 8th Edition of the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health (NIH, revised 2011) and were in accordance with the Animal Management Rules of China (Documentation 55, 2001, Ministry of Health, China)

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in addition, mRNA expression of GPx7 was significantly upregulated in mice suffering from MASH fibrosis as compared to healthy controls as well as mice with simple steatosis (Kim et al