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Our results show the plasticity of AhpC, which under selective pressure can be altered by different mutations to channel electrons into ribonucelotide reductase by at least four distinct routes, acting via glutathione, -Glu-Cys, the thioredoxins or glutaredoxin 1

In L-thyroxine-induced depression in mice, catalpol inhibited the Cyclooxygenase-2/NLRP3 signaling pathway, reducing neuronal damage and exhibiting antidepressant effects

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Summary Keywords monocarboxylate transport, neurodegenerative disease, Schwann cell, oligodendrocyte, astrocyte, peripheral nerve, lactate Citation Jha MK and Morrison BM (2020) Lactate Transporters Mediate Glia-Neuron Metabolic Crosstalk in Homeostasis and Disease