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These Rh2-loaded ASP nanoparticles enhanced SCFA production, particularly acetate, propionate, and butyrate, and upregulated ZO-1 expression in colonic tissues, thereby improving mucosal barrier homeostasis (232)

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The Pharmaceutical Benefits Advisory Committee will need to weigh the broad availability of incretin analogues for obesity management against the long-term health and economic costs of obesity to the Australian community