This is evident in children with obesity and asthma, where impaired glucose and insulin metabolism is associated with significantly increased AHR, both dependent and independent of BMI [44]
By midlife, many adults have 40 to 50% less NAD+ than they did in their 20s
Rev Bras Farmacogn 29:325332 Roos TU, Heiss EH, Schwaiberger AV, Schachner D, Sroka IM, Oberan T, Vollmar AM, Dirsch VM (2011) Caffeic acid phenethyl ester inhibits PDGF-induced proliferation of vascular smooth muscle cells via activation of p38 MAPK, HIF-1, and Heme oxygenase-1
instead, it exerts its protective effects through multi-target modulation of key inflammatory, oxidative, fibrotic, and proliferative pathways (Stachelska et al., 2025)
Biochemical pharmacology 38 , 823830, (1989)