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evaluated rats subjected to 45 min of bilateral renal ischemia for 9 months and observed significant mitochondrial damage in their endothelial cells, podocytes, and proximal tubular cells

Plasma vitamin C, but not vitamin E, is associated with reduced risk of heart failure in older men

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Targeting these molecules with neutralizing antibodies or small-molecule antagonists (e.g., glycyrrhizin) has demonstrated BBB-stabilizing effects in vivo , including reductions in brain edema and vascular permeability (Lochhead et al., 2020