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Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability

Its complementary mechanisms enhance the effects of growth hormone secretagogues, other healing peptides, and mitochondrial-targeting compounds

10.1159/000516396 144 LiuQ.WangJ.GuZ.OuyangT.GaoH.KanH.et al (2024)

Oral small molecules beyond orforglipron, additional dual agonists, and standalone amylin agents are all in Phase 2, reflecting a field that is no longer betting on one approach

In the Phase III MARCH trial, which enrolled 93 patients across several different genetic subtypes of PFIC, Livmarli significantly improved pruritus symptoms in treated patients, as well as concentrations of serum bile acids and bilirubin