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By contrast, PD-1 antibodies primarily function by blocking PD-1/PD-L1 interaction and exhibit more limited effects on broad TME remodeling

Thats because it doesnt specifically work on just one type of hormone receptor

Liao J, Schneider A, Datta NS, McCauley LK

Ki67 is present during all active phases of the cell cycle (G1, S, G2, and M) but absent in resting cells (G0), making it a key marker for assessing tumor cell proliferation

However, unlike glycolytic and lipogenic pathways, where specific metabolic enzymes such as hexokinase 2 and FAS are known to be deregulated by oncogene(s) or by inactivation of tumor suppressors 16,17 , there is limited evidence for cancer-associated abnormal expression or activity of the enzymes directly involved in the FAO pathway