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SFAs are also thought to directly induce an inflammatory response in the brain by activating toll-like receptor (TLR) receptors in microglia, causing elevated cytokines IL-6, interleukin-1 (IL-1), and TNF-, particularly in the hippocampus, which has been shown to correlate with depressive behavior in mice (3234)

PPC is then decarboxylated to 4-phosphopantetheine via the action of phosphopantothenoylcysteine decarboxylase (PPCDC)