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[8] [9] As a precautionary measure, consistent with SmPC guidance for the drug class, retatrutide would be expected to be contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) Patients who are pregnant, breastfeeding, or planning pregnancy should not use retatrutide, consistent with guidance applicable to other agents in this class

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As a prescription-only medication manufactured under strict FDA oversight, tirzepatide has undergone safety and efficacy review that over-the-counter patches have not