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10.3945/ajcn.2008.26615 31
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These clear effects (observed through comparison with various comparators, including current weekly GLP1-RAs on the market) are complemented by interesting data on cardiovascular safety and efficacy (from post-hoc studies) regarding the incidence and progression of nephropathy and hepatic steatosis
Long-term effects, interactions, and effects in any special population are entirely uncharacterized
Notably, reactive astrocytes closely interact with A plaques and degrade A plaques in an apolipoprotein E epsilon 4 (APOE) gene-dependent manner by releasing amyloid-degrading enzymes such as insulin-degrading enzyme (IDE) and matrix metalloproteinases (MMP-2, MMP-9) 48,49
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