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Oral semaglutide may cause slightly different nausea patterns because it is absorbed through the stomach lining, while the injection delivers the drug systemically

51 One significant challenge is the high rate of gastrointestinal adverse events associated with these compounds, which may be related to their pharmacokinetic properties and direct gastrointestinal irritation

The broader benefits beyond glucose control are increasingly recognised in clinical decision-making, though prescribing decisions should be individualised based on patient characteristics, comorbidities, and treatment goals

doi:10.4088/pcc.v09n0105

M., Pickart F