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De novo protein-altering mutations in BD probands led to noticeably earlier disease onset compared to non-carriers ( 5 Approaches to validate the NDD-cancer connection hypothesis We hypothesized that one major cause for the emergence of NDDs and cancertwo diseases (or conditions) with vastly different clinical featuresis the mutation load in the same genes

doi:10.1080/07315724.2004.10719400 Lepping P, Huber M

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