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And since GLP-1s promote weight loss, which can reduce bone density, bone health becomes an active concern, says Allidina

semaglutide, people without type 2 diabetes who took: Tirzepatide experienced an average weight loss of 20.2% after 72 weeks (~16.5 months) Semaglutide experienced an average weight loss of 13.7%after 72 weeks (~16.5 months) A 2024 cohort study of people with obesity or overweight outside of a clinical trial also compared tirzepatide vs