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Given the lack of liver GLP-1R expression (136), the potential mechanism of actions of GLP-1R agonists in NASH may be related to the indirect beneficial effects on body weight, IR and reduction in metabolic dysfunction, lipotoxic effects and inflammation (137)
doi:10.4068/cmj.2018.54.3.135
The point estimate of the ratio (ESRD group/normal renal function group) for AUC 48 (without hemodialysis) was 0.72 (90% CI 0.570.91) and for AUC 4896 (with hemodialysis) was 0.82 (90% CI 0.670.99)
Local injection site reactions are the most common and typically include: Erythema (redness) and warmth at the injection site Swelling or induration (hardening of tissue) Pruritus (itching) or discomfort Bruising or nodule formation in some cases (particularly with exenatide extended-release formulations, where nodules are common and often non-allergic) These reactions usually appear within hours of injection and may resolve spontaneously within a few days
All doses of both drugs increased the risk of stomach side effects compared to placebo
