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The most frequently reported side effects in Phase 2 trials are gastrointestinal: nausea, vomiting, diarrhoea, and constipation, typically dose-dependent and mild to moderate

Like any medication, both retatrutide and semaglutide come with possible side effects, most of which are mild and temporary

Human mtDNA is not shielded by histones, and thus it is easily damaged and the repair process is very slow (Shigenaga et al., 1994)

The intestinal carnitine pool plays an important role in the communication system of the gutorgan axis, and it can directly affect remote organs by remodeling intestinal carnitine metabolism

Therefore, medications that facilitate weight loss may have opposing effects on menstruation depending on the individual's baseline metabolic and hormonal status