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Paracetamol is generally safe under normal conditions and at the recommended dose (200 mg/kg in children or 6000 to 7000 mg in adults per day) (Tittarelli et al., 2017)

Clinical: 1.0% topical idebenone reduced roughness/dryness (26%), increased hydration (+37%), reduced fine lines (29%), and improved overall photodamage (+33%) in 6 weeks

However, with the prevalence of skin permeation enhancement methods (such as microneedles and laser) used in cosmetic and pharmaceutical industry 15 , copper compounds may pose a higher risk to cause skin irritation, which necessitates a thorough skin toxicity testing

Glutathione S -transferase activity and subunit composition in transitional cell cancer and mucosa of the human bladder