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Q3: How long before results show

The area postrema (AP) is a circumventricular organ of the hindbrain with a leaky blood-brain barrier, previously identified as a region associated with nausea and vomiting [100,101]

The smaller number of COM crystal receptors on the apical membranes of the trigonellinetreated cells affirmed the downregulation of some of these crystal receptors by trigonelline

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One may argue that with extended half-life, therapeutic agents GLP-1RAs are resistant to DPP-4 mediated degradation, allowing them to reach to the brain to exert their anorexic and other brain functions directly