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Key considerations include: Always inform your GP or pharmacist about all medications you are taking, including over-the-counter products like paracetamol Follow the recommended dosing instructions for both medications Take Rybelsus on an empty stomach as directed (at least 30 minutes before food or other medications) with no more than 120ml of water

Injecting in the same location repeatedly increases the risk of lipodystrophyvisible dents or lumpy tissue under the skinwhich can affect medication absorption

A 2021 review found the drug slows gastric emptying by 30 to 70 percent in early weeks, which changes how minerals move through the gut, per PubMed

Three weeks at 10 mg

GLP-1 receptor agonists do not appear to act in this way