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GLP-1 agonists may be preferable in some elderly patients due to lower hypoglycemia risk, though GI side effects and potential for weight loss (which can be undesirable in frail elderly patients) require careful consideration

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Figure 5 Downstream cellular mediators of Dihexa protection Activation of the receptor tyrosine kinase c-Met leads to the recruitment of many signaling mediators and ultimately the activation of downstream signals, most notably Akt-TOR and Ras-ERK (Organ and Tsao, 6A)

The second step consists of adding hydrogen and partial charges using Autodock Tools (ADT, version 1.5.4)

using calibrated laboratory equipment where appropriate