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Melatonin is a circadian hormone that primarily times the sleep-wake rhythm

Notably, binding of MyD88 to interleukin-1 receptor-associated kinase 4 (IRAK4), and activation of p38 mitogen-activated protein kinase (MAPK) and NF-B p65 were significantly impaired in MyD88 where Cys113 was replaced with alanine, indicating the significance of Cys113 palmitoylation in facilitating TLR signaling

doi: 10.1002/erv.2931

Haematologica 98 , 13751382 (2013)

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