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For the TG clearance tests, mice were fasted overnight (~15 h), then administered 20% intralipid (Sigma-Aldrich) via oral gavage (15 l g 1 body weight) at ZT2

10 Safety and Tolerability One advantage of SGLT2 inhibitors, compared with several other glucose-lowering therapies, is the low potential to induce hypoglycemia, unless combined with insulin or insulin secretagogues [25]

We're talking days, not weeks or months

Starting body composition plays a major role, with individuals carrying higher body fat percentages often experiencing more dramatic absolute changes, while leaner individuals may see slower but steady improvements in stubborn fat areas

The authors declare that they have no competing interests