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According to the working model, these cysteine residues may undergo chemical modification/remodeling including trisulfide bond formation and/or related reactions, resulting in a regional (minor, but effective) structural alteration that enhances c-met binding and the nitration resistance of Y198-HGF

Svensson J, Lall S, Dickson SL, Bengtsson BA, Rmer J, Ahnfelt-Rnne I, Ohlsson C, Jansson JO

It plays a central role in several vital functions

That does not mean instant rebound. It means tesamorelin is not usually framed in the literature as a one-and-done intervention