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A potentially more clinically realistic analysis testing the impact of continuing oral semaglutide and liraglutide alongside basal insulin therapy before intensification to basal-bolus insulin was also explored, and this showed further benefits in clinical outcomes and cost-effectiveness were possible with oral semaglutide (Table 3 and Fig

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It is also why rushing to a higher dose in the first week or two before steady state is reached often leads to unnecessary side effects

Neurochemistry Int