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A 2019 meta-analysis noted mixed outcomes in autoimmune thyroid conditions, with some studies showing reduced TPO antibodies and improved TSH control, while others showed minimal clinical benefit

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It has reported that PQQ exerts its effects through several key molecular mechanisms, including the activation of antioxidant pathways via Nrf2/ARE signaling, enhancement of mitochondrial biogenesis and function through AMPK/PGC-1, and the regulation of inflammatory processes through NF-B inhibition