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Subcutaneous injection near wound sites delivers concentrated peptide directly to healing tissue while also providing systemic distribution that may support overall repair processes

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Research shows no evidence of tolerance, no withdrawal effects on discontinuation, no organ toxicity with extended use, and no hormonal disruption

2009 Jun;329(3):1110-6

Thus, researchers, clinicians, advocates and policy-makers should consider viewing the burden and management of spinal degeneration holistically as part of the OA disease continuum