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Thus, the decrease in SREBP2 transcription will lead to a decrease in LDL receptor activity and a reduction in cholesterol uptake, while simultaneously, a decrease in miR-33 will lead to an increase in LXR activity stimulating the expression of ABCA1 and ABCG1 resulting in increased cholesterol efflux

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Trials commonly began at a low once-weekly dose (around 0.25 mg) and escalated in roughly 4-week steps, with 2.4 mg once weekly being the most-studied maintenance example and doses up to 4.5 mg examined in dose-finding work

doi: 10.3390/ph16091216 79 GargusM.Ben-AzuB.LandwehrA.DunnJ.ErricoJ