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10.1016/j.algal.2020.102104 55 GhaniM

When to discard Discard tirzepatide immediately if: The printed expiration date or beyond-use date has passed The solution is cloudy, discolored, or contains particles The vial has been at room temperature for more than 21 days (brand-name) or past your pharmacy's specified window (compounded) The medication has been frozen at any point The medication has been exposed to temperatures above 86 degrees Fahrenheit An opened vial has been punctured for more than 28 days You are unsure of the storage history The container shows any damage or leakage When in doubt, throw it out

That cleared one of the biggest worries going in

But for most people, once the first couple of injections go smoothly, confidence builds fast

Retatrutide decreased HbA1c by 2.02% in a phase II clinical trial, while dulaglutide 1.5 mg decreased HbA1c by 1.14% and a placebo decreased it by 0.01% [109]