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May 19, 2022
Consequently, CHAC1 serves as a central mediator connecting ISR (ATF4) to the antioxidant response (NRF2) and metabolic adaptation (SLC7A11), thereby enabling cells to dynamically fine-tune redox homeostasis and maintain metabolic flexibility during stress (Kre et al., 2023)
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We searched primary electronic databases, including PubMed, Web of Science, and Google Scholar, for articles published from their inception up to February 2026
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