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La inmadurez del sistema hepatobiliar, la menor reutilizacin y sntesis de sales biliares, la reduccin de la circulacin enteroheptica producto de la condicin que gener la AP, la menor capacidad de conjugacin de esta va biliar inmadura y la menor disponibilidad del sistema glutatin-dependiente son los factores que explican esta asociacin (14, 15)