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For the healthy controls, the absence of any psychiatric diagnosis and substance misuse were assessed by a trained psychiatrist and verified using the Patient Health Questionnaire-9 (PHQ-9)

SOD activity was assayed by measuring the dismutation of superoxide radicals generated by xanthine oxidase and hypoxanthine

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This sets up a vicious loop: hyperglycemia oxidative stress low GSH worse insulin resistance more hyperglycemia

9 for D--glucose, D--fructose and D-sucrose, the activation energy at a level of 300600 kJmol 1 , was observed for small conversions, = 0 _{\text{0i ^{\text{SV \)(400 K) = (194 5) kJmol 1 [58]