These data suggest that there is space for safer and tolerated best in class cAMP lowering approaches in ADPKD either targeting additional pathways regulating cAMP (PKA inhibition, PDE activation), biased V2R antagonists or combination with targets that may provide an additive or synergistic effect such as the calcium-sensing receptor (Zhou and Torres, 2022)
In contrast to traditional expectations, a patient may appear compliant with fasting guidelines but still have a full stomach
You can read more about GLP-1RAs and the kidney in NephMadness 2024 (Animal House region)
Heres how to live your best metabolically supported life: Move That Body Exercise is the ultimate GLP-1 boost
Together, they form GlyNAC, which increases glutathione by 200% (NIH) and improves mitochondrial function by 83% (NIH), supporting detoxification, energy, and longevity