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One limitation of the feedback control system used here for potential application in biomanufacturing is its use for a natural product regulated by feedback inhibition

JAMA 282 , 15681575 (1999)

Regulation of Metabolic Processes: It influences metabolic pathways, including fat and carbohydrate metabolism, thereby impacting overall metabolic health

A similar rationale underpins regimens for Friedreichs ataxia, where riboflavin plus antioxidants (CoQ10, -lipoic acid) counter mitochondrial ironsulfur-cluster loss and free-radical injury, offering symptom relief beyond monotherapy (79, 80)

GR activity demonstrated a large effect size, whereas GPx showed a negligible effect