doi: 10.2141/jpsa.46.169 62
DEM exposure resulted in a clear accumulation of Keap1-GFP in cytoplasmic autophagosomal foci, an accumulation of Nrf2-GFP in the nucleus and an accumulation of Srxn1-GFP in the cytoplasm, which is in agreement with the current qualitative understanding of the Nrf2 pathway
Glutathione suppresses production of melanin-producing substances and also changes existing melanin to light-colored pheomelanin
Particularly in the field of IPF, various biomarkers related to the mechanistic pathway such as alveolar dysfunction (MUC5B, telomerase), immune dysregulation (monocyte, heat shock protein 70, S100A12), extracellular matrix remodelling (collagen degradation biomarkers) have been proposed, however there is a need for high-quality, implementation research to bring these biomarkers into daily clinical practice 26
Repeated administration of 50% of the LD 50 (i.e., 40 mg/kg body weight per day for 10 - 21 days), caused myelin pallor and micro-vacuolation of the white matter
