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Fe showed weak, non-significant mediation ( = 0.08 ), while MDA ( = 0.15, CI: 0.030.26) and GSH ( = 0.33, CI: 0.160.54) had significant effects, with GSH playing a dominant mediating role

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For instance, single-cell RNA sequencing of microglia in germ-free vs colonized mice with neurodegenerative pathology can pinpoint microglial genes influenced by the microbiome

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What emerges is a coherent biological framework: estrogen maintains the mitochondrial infrastructure and synaptic stability that neurons depend on for sustained function, while GLP-1 receptor activation reduces the inflammatory burden that progressively degrades that infrastructure