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In patients with primary insomnia, exogenous melatonin demonstrates significant effects on several sleep parameters such as sleep onset latency, total sleep time, morning alertness, and sleep quality, as reviewed in several recent systematic reviews and meta-analyses [15, 16]

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If cortisol dysregulation or anxiety is the primary sleep disruptor, Selank may be the first-line intervention

The apoptotic index was calculated as the sum of early apoptotic and late apoptotic cell populations [1]