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These findings align with previous evidence of CAR T cells from non-responders or early relapsed patients stimulated with CD19 that displayed transcriptional programs associated with dysfunctional mTOR signaling and lower metabolic activity 24

Glutathiones role in mitigating oxidative stress could contribute to a more resilient response to daily challenges

113 , 114 , 115 , 116 Although comparisons between different studies are limited, the proportion of patients who experienced hyperpigmentation was greater than that among those treated with afamelanotide