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The original clinical development, by the Canadian biotech ConjuChem, was discontinued, and there is no validated disease endpoint for either version
The benefit comes from replacing whats missing, not from extra B12 on top of normal levels
Using this mechanism, we obtained EHR data from 909 participants with a recorded GLP1 medication prescription (Supplementary Table 5)
Without this factor, vitamin B12 cannot be absorbed even if the anatomy is intact
Adoption of these agents was underwhelming, however ( ) and tirzepatide (Zepbound ), approved for the treatment of obesity in 2021 and 2024, respectively, produced corresponding mean weight loss of 17% and 23% in clinical trials of subjects with obesity, but without T2D ( It is not a coincidence that AOMs are demonstrating progressively superior effectiveness
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