retatrutide nonalcoholic fatty liver disease trial steatohepatitis nash in Patients with Type 2 Diabetes: Screening, Diagnosis, and Treatment Oligonucleotide therapies for nonalcoholic steatohepatitis – PDF) Triple hormone receptor agonist

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MASH resolution without worsening of fibrosis: 2.4 mg dose: 47% of participants (vs 14% placebo) 4.8 mg dose: 62% of participants (vs 14% placebo) 6.0 mg dose: 43% of participants (vs 14% placebo) Liver fat reduction of at least 30%: 2.4 mg dose: 63% of participants 4.8 mg dose: 67% of participants 6.0 mg dose: 57% of participants Placebo: 14% of participants Fibrosis improvement by at least one stage: Survodutide groups: 34-36% Placebo: 22% The percentage change from baseline in liver fat content after 48 weeks was a staggering 62% reduction in the 6.0 mg group, compared to just 5.7% in the placebo group

Together, these effects shift the balance of beta cell proliferation and apoptosis in favour of proliferation, so the peptide could be used to treat diabetes and provide protection to the pancreas from damage that negatively affects beta cells

Peer-reviewed data, like NEJM 2023, keep reinforcing Retatrutides potential

When these GLP-1r / mice were treated with calcitonin, the increase in urinary DPD concentration was alleviated