They showed that semaglutide enhanced histological parameters of fibrosis and inflammation while decreasing hepatic expression of genes associated with fibrotic and inflammatory cascade: through proteomic profiling of serum from MASH patients treated with semaglutide, they detected 72 proteins linked to disease resolution and validated these findings in preclinical mouse models and an independent patient cohort [28]

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Patzelt C, Labrecque AD, Duguid JR, et al
Modulation of basophil activity: a novel function of the neuropeptide melanocytestimulating hormone
The abstract (but not the complete study) for the SURMOUNT-OSA trial was just published in the New England Journal of Medicine