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The mechanism of action has been determined that KPV inhibits the activation of NF-kappaB and MAP kinase inflammatory signaling pathways, and reduces pro-inflammatory cytokine secretionacts via PepT1 expressed in immune and intestinal epithelial cells..[and] reduces the incidence of DSS- and TNBS-induced colitis indicated by a decrease in pro-inflammatory cytokine expression (Dalmasso et al., 2008)

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Evidence that human class Theta glutathione S-transferase T1-1 can catalyse the activation of dichloromethane, a liver and lung carcinogen in the mouse

doi: 10.1038/s41467-018-04366-7 129 SiskaPJJiaoJMatosCSingerKDettmerKOefnerPJet al