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In fact, the inhibition of lever pressing induced by central administration of exendin-4 is replicated in rats by specific infusion into the NTS [67,68,86], suggesting that the NTS may be mediating the effects of peripheral GLP-1 analog administration on effort-based food-motivated behavior
Other transporters, which have been actively investigated for brain delivery of drugs are glucose transporters (GLUTs, encoded by SLC2A genes)
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Reactive oxygen species that play the greatest role in the initiation of oxidative stress include hydrogen peroxide, superoxide anion radical, and hydroxyl radical (82)
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