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5 The absolute risk increase is small (around 3 extra cases for every 1,000 people taking the medication for a year), and the effect is partly explained by weight loss rather than the medication itself

The sample was lyophilized (Alpha 1-2 LDplus, Martin Christ Gefriertrocknungsanlagen, Osterode am Harz, Germany), finely ground (EGK 200, Rommelsbacher, Dinkelsbhl, Germany), thoroughly homogenized, and stored at 20 C in the dark until further analysis

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