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Eric Topol of Scripps Research Translational Institute was more direct: "These peptides have no data to support their safety and efficacy." The clinical proponents argue that the FDA's safety concerns immunogenicity risk, impurity risk, organ toxicity are theoretically valid but speculative in practice

Further biochemical, cryogenic electron microscopy (cryo-EM) and X-ray crystallography analyses uncover that IpaH1.4 can specifically recognize the RING domain of RNF213 through its LRR domain