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Assessment report Article 53 procedure for GLP-1 based therapies

Notably, while long-acting GIPR agonists act in the brain in a GLP-1R-independent manner to decrease body weight and food intake via GABAergic GIPR neurons, GIPR antagonism also decreases body weight and food intake in DIO mice and non-human primates, particularly when used in co-therapy with GLP-1R agonism 22,23,24,25,26,27,28

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