While this methylation reaction was historically considered a relatively minor metabolic pathway for nicotinamide clearance, research over the past decade has revealed that NNMT plays a surprisingly important and previously underappreciated role in cellular energy metabolism, NAD+ homeostasis, adipocyte biology, and whole-body metabolic regulation
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The mechanisms are multi-layered
Studies have examined their effects on wound healing in diabetic patients, collagen synthesis in human skin, hair follicle enlargement and gene expression in skin cells
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