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However, for drugs such as lithium, milnacipran, pregabalin, and gabapentin that are not metabolized or little metabolized, and that are eliminated by renal excretion, 10 half-life increases in proportion to the severity of the renal disease

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Multi-Omics Factor Analysis (MOFA): MOFA was performed using the MOFA2 R package to integrate multi-omics data

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