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GLP-1R regulates brain glucose metabolism The most prominent physiological effect of GLP-1 and GLP-1R is the regulation of insulin secretion in the pancreas to maintain postprandial glucose homeostasis, whereas outside the pancreas, GLP-1 and GLP-1R also regulate feeding and metabolism through the nervous system

A systematic review and meta-analysis published in 2020 found that liraglutide treatment resulted in significant reductions in body weight (mean difference approximately 4-5 kg compared to placebo or metformin), improved insulin sensitivity markers, and favourable changes in lipid profiles

doi:10.1016/j.jaad.2015.07.017 30Botelho LF, Picosse FR, Padilha MH, Michalany N, Gis A, Porro AM