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It activates the PI3K/Akt pathway, leading to eNOS activation and NO production, which promotes vasodilation and anti-inflammatory effects [214]

During the first 24 weeks, you may experience: Nausea (the most frequently reported side effect, affecting 20-40% of patients initially, varying by product and dose according to SmPC data) [20] [17] Reduced appetite or early satiety Occasional vomiting Mild abdominal discomfort or bloating Changes in bowel habits, including constipation or diarrhoea These effects typically diminish as your body adjusts to the medication, usually within 48 weeks

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Vergari E, Knudsen JG, Ramracheya R et al (2019) Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Peptides augment but don't replace standard fracture management