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When the liver accumulates fat, it becomes vulnerable to cellular damage from reactive oxygen species (ROS), which are unstable molecules that can harm cellular structures

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The lack of efficacy of inhaled GSH in patients with cystic fibrosis could be explained by the high concentrations of the GSH-degrading enzyme -glutamyltransferase present in lung fluids of those patients (116123), and then, the use of precursors of GSH synthesis like NAC and cystine could be more effective in the synthesis of GSH (124)

However, melatonin has also been shown to upregulate NMDA receptor subunits 2A and 2B in a dose-dependent manner in the rat hippocampus [80]

Melatonin is a free-radical scavenger (18) (38) and enhances antioxidative enzyme activities (39) , interacting with cytosolic calmodulin and stimulating IL-4 production in bone marrow T-lymphocytes (1)